CORDIS Project
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This project focuses on improving human heart cell models derived from induced pluripotent stem cells to better understand cardiac arrhythmias. By enhancing the maturation of these cells, it aims to identify genetic markers linked to cardiac diseases, facilitating personalized drug testing and reducing reliance on anim…
The incidence of cardiac arrhythmias in Europe is increasing because of aging and unexpected side effects of drugs, such as chemotherapeutics.
To understand mechanisms underlying these conditions requires reliable preferably human models.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are presently good candidates since they share the genome of the individual from whom they are derived and can thus recapitulate genetic, ethnic and gender contributions to the cardiac disea…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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