CORDIS Project
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This project focuses on developing a non-invasive method to monitor pancreatic β-cell function and survival in living organisms using genetically engineered islet organoids. By transplanting these organoids into the eye of mice, researchers aim to create a platform for testing new diabetes treatments.
To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution.
We therefore transplant genetically engineered sensor islet organoids into the anterior chamber of the eye of mice for functional microscopic imaging.
Using the cornea as a natural body-window, following their engraftment various aspects of β-cell function and…
KAROLINSKA INSTITUTET
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