CORDIS Project
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This project aims to enhance single-molecule fluorescence spectroscopy by utilizing nano-apertures and DNA nanostructures. The goal is to enable high-concentration studies for applications in drug screening and medical diagnostics, facilitating significant advancements in single-molecule analysis.
In order to advance single-molecule fluorescence spectroscopy to the next level, handling and analysis of single molecules has to become broadly available.
A further quantum leap is required to proceed to commercially successful applications such as drug screening and medical diagnostics.In this project, I suggest a strategy to overcome the fundamental gap between the nanomolar concentration regime of current optical single-molecule spectroscopy and the nano- to millimolar dissociation constants…
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