CORDIS Project
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This project aims to develop multiscale simulation technology for studying DNA, addressing current limitations in accuracy and scale. It focuses on creating a comprehensive model that can analyze DNA from the atomic level to the human genome, enhancing our understanding of genetic structure and regulation.
The availability of new computers and software is making possible the theoretical representation of DNA, increasing then our knowledge on the behavior of one of the most relevant biological macromolecules.
Unfortunately, current simulation procedures present two major problems, which handicapped their use: i) classical force-fields present well known biases, which limit their accuracy; ii) current atomistic procedures are limited to study systems in the range of 100 base pairs (around 34 nm long…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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