CORDIS Project
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This project focuses on developing a simplified kit for RNA base editing using the SNAP-ADAR tool, making it accessible for life scientists without specialized chemistry skills. The kit aims to facilitate precise editing in mammalian cells, enhancing research in protein function modulation and drug discovery.
RNA base editing is a promising approach to manipulate genetic information in a transient and dosable way, which breaks new ground in basic Life Science research and drug discovery.
In a preceding ERC CoG action, we have engineered the SNAP-ADAR tool, which allows for the particularly precise, efficient and programmable adenosine-to-inosine RNA base editing.
However, the broad usage of this tool is somewhat hampered by the need for designing the chemically modified guideRNAs, which currently inc…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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