CORDIS Project
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This project aims to create an in vitro model to study human immune responses to vaccine adjuvants. It focuses on how adjuvants influence the activation of immune cells and the subsequent T cell responses, using candidate vaccines to analyze the quality and magnitude of the immune reaction.
The aim of the proposal is to construct an in vitro model of human cellular immune responses and to address fundamental questions on the link between vaccine adjuvants and the adaptive immune response.
One emerging concept of adjuvant-stimulated immune activation is that monocytes are recruited from the blood to the injection site and differentiate into either macrophages or dendritic cells (DCs).
The DC then migrate to the draining lymph nodes to activate adaptive immunity.
The first objective…
GLAXOSMITHKLINE BIOLOGICALS SA
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