CORDIS Project
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SiMulTox develops an innovative platform for assessing both functional and structural cardiotoxicity in cardiac cell cultures. By combining long-term electrophysiological recordings and live-cell imaging, it aims to improve drug safety evaluations and support drug development processes.
Cardiac drug-related adverse effects have been the major causes for the failure or withdrawal of drugs from the market.
With a growing global market, cardiotoxicity still remains a bottleneck in the chain of drug development.
Despite the large investments in drug discovery and development, the number of approved drugs has been declining.
Current in-vitro technologies assess functional cardiotoxicity relying on short-term electrophysiological recordings (detection of cardiac Action Potentials, AP…
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