CORDIS Project
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This project develops innovative technologies to visualize the composition of ion channels at individual synapses using advanced electron microscopy techniques. It aims to understand how changes in channel composition affect synaptic plasticity and behavior in mice through optogenetic stimulation and genetic manipulati…
Ligand-gated and voltage-gated channels are key molecules in transforming chemical signals into electrical ones and electrical signals into chemical ones, respectively.
At excitatory synaptic connections in the brain, activation of AMPA- and NMDA-type glutamate receptors elicits inward currents at the postsynaptic sites, and activation of voltage-gated calcium channels triggers vesicle release of glutamate in the presynaptic sites.
Plastic changes in their number, location and property can lead…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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