CORDIS Project
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This project aims to enhance our understanding of how cells can be reprogrammed into induced pluripotent stem cells by using advanced mass cytometry techniques. It focuses on tracking gene expression and epigenetic changes at the single-cell level, ultimately aiming to identify key markers that predict cell fate during…
The demonstration of induced pluripotency and direct lineage conversion of cells has led to remarkable insights regarding the roles of epigenetic modifications in mediating cell state transitions.
However, approaches to elucidate the molecular mechanisms behind induced reprogramming are hindered by the inefficiency of induction and the interplay of reprogramming mechanisms with other cellular processes such as the cell cycle, which leads to variability in induced cell populations and limits the…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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