CORDIS Project
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This project investigates unusual DNA structures, such as triplexes and G-quadruplexes, using magnetic tweezers to understand their behavior in near-physiological conditions. The goal is to explore their interactions with ligands, which could inform drug design for genetic diseases.
Certain nucleic acids sequences can form unusual structures, like triplexes, G-quadruplexes and i-motif.
Nowadays, several genetic diseases have proved to be mediated by the formation of non-B DNA structures at certain chromosomal locations.
Therefore, it is very important to inversigate these unusual DNA structures, which may well be biologically relevant, at the molecular level.
To study the function of such unusual DNA structures in vivo, it is important to understand how they assemble and in…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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