CORDIS Project
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This project aims to understand the mechanisms of Alzheimer's disease by studying the behavior of amyloid-beta oligomers at a single molecule level. It focuses on their interaction with neuronal cell membranes and the influence of cholesterol on their mobility.
Fibrillar deposits of proteins are the hallmark of amyloid diseases, amongst which Alzheimer’s disease stands out as the most widespread neurodegenerative pathology of the brain.
Neuronal dysfunction is currently attributed to the interaction of A-beta oligomers with the plasma membrane.
Several scenarios have been proposed, but the mechanisms of binding of the oligomers to the cell membrane and their subsequent toxicity is still unclear.
The dependence of the proteolytic production of A-beta pe…
LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI
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