CORDIS Project
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This research focuses on the communication between neurons and microglia during brain development, particularly the role of sialic acid in synaptic pruning. The project aims to uncover the molecular mechanisms that regulate these interactions and their impact on neural circuits.
Effective neuron-microglial communication is a prerequisite to achieve the final connectome.
It is mediated by both the formation of new synapses and selective removal of unnecessary connections through synaptic pruning.
Recent evidences suggest that superfluous connections are eliminated by microglia.
Almost 70% of the connections are lost in a primate cortex within six months of life.
But what drives this selective elimination of so many synapses is a million-euro question.
Identifying neurona…
VILNIAUS UNIVERSITETAS
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