CORDIS Project
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This project explores the role of SIRT6, a protein involved in aging and metabolism, to understand its impact on lifespan and metabolic diseases. It aims to identify SIRT6 substrates and develop small molecules that activate SIRT6 for potential therapeutic applications.
The significant increase in the human lifespan during the last century confronts us with great medical challenges.
To answer them, one must understand and control the mechanisms that determine the rate of ageing.
The sirtuins, and in particular the mammalian member SIRT6, are a family of NAD+ dependent deacetylases that were implicated in ageing and the regulation of metabolism.
Much evidence correlates SIRT6 with the regulation of ageing, primarily the manifestation of ageing related pathologie…
BAR ILAN UNIVERSITY
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