CORDIS Project
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The SIRENseek project focuses on identifying and characterizing silencer elements and their associated proteins in the genome. By employing advanced proteomic and epigenomic techniques, the project aims to understand how these silencers regulate gene expression, potentially paving the way for targeted therapies in vari…
Distal regulatory elements in the genome play a key role in orchestrating tissue- and context- specific transcriptional programs.
While activating elements (enhancers) have been broadly studied in the last decades, repressive elements (silencers) remain a ‘mysterious’ class of regulatory regions of the genome, whose characteristics have never been systematically elucidated.
In the ""seeking the SIlencer-associated REpressive protein Network” (SIRENseek) project, I aim to identify and functionall…
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