CORDIS Project
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This project investigates the role of sirtuin genes in metabolism and their potential impact on longevity. By creating genetically engineered mouse models and studying natural genetic variations, it aims to uncover the contributions of these genes to metabolic health and disease prevention.
By modulating the activity of transcription factors, cofactors influence cellular and organismal metabolic pathways.
Recently the role of the sirtuin cofactor gene family received a lot of attention in this context, as their beneficial impact on longevity was linked to effects on metabolic control.
Most sirtuins catalyze deacetylation reactions that are tightly linked to cellular energy (NAD+) levels.
To ascertain the tissue-specific contributions of sirtuins in metabolism, we propose here to: 1…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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