CORDIS Project
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This project investigates the use of small interfering RNA to suppress tau protein expression in mouse models of neurodegenerative disorders. It aims to prevent neuronal loss and cognitive deficits associated with tauopathies, potentially advancing treatment options.
Neurodegenerative disorders are an increasing healthcare problem.
Many of these diseases are characterized by aggregation of proteins, which leads to neuronal dysregulation and cell death.
Neurofibrillary tangles, pathological aggregates of tau protein, are the characteristic neuropathological stigmata defining a group of disorders termed Tauopathies.
In Frontotemporal Dementias with Parkinsonism linked to Chromosome 17 (FTDP-17), mutations in the tau gene have been identified as cause of the di…
PHILIPPS UNIVERSITAET MARBURG
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