CORDIS Project
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This project investigates the role of DNA damage in cancer and aging, focusing on nucleotide excision repair deficiencies. It explores how specific cellular responses to DNA lesions affect growth regulation and longevity, aiming to develop new strategies for skin cancer treatment and insights into aging biology.
DNA damage has been implicated as a causal factor of cancer development and is thought to contribute to aging.
The effect of DNA damage both in cancer and aging becomes particularly apparent in patients that are defective in nucleotide excision repair (NER). NER comprises two distinct branches that differ in the initial damage recognition and lead to distinct clinical outcomes.
Global genome (GG) NER recognizes damages throughout the genome, whereas transcription-coupled repair (TCR) specificall…
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