CORDIS Project
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This research explores the role of connexins in skin health, particularly how mutations affect calcium signaling and keratinocyte behavior. The project aims to understand the mechanisms behind skin disorders linked to connexin mutations through cellular and 3D modeling studies.
The skin protects the body against environmental insults and to function properly, epidermal keratinocytes maintain a perfect balance between proliferation and differentiation.
Alteration of this balance leads to disorders.
Some of these diseases are linked to connexin (Cx) mutations.
Connexins are widely expressed in all layers of the epidermis but exact roles of connexins in the epidermis are not known.
Analysis of disease mutations can be invaluable for understanding connexin function.
Connex…
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