CORDIS Project
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This project focuses on understanding the role of matrix metalloproteinase-10 in skin cancer and wound healing. It employs advanced proteomic techniques to identify its substrates and their implications in skin carcinogenesis.
Matrix metalloproteinases (MMPs) regulate processes within the dermal and the epidermal compartments and particularly at the epidermal – dermal interface.
This is of crucial importance for wound repair and also for the pathogenesis of skin cancer.
One member of the MMP family - MMP-10 - gained particular interest, since it is specifically expressed at the leading edge of hyperproliferative keratinocytes in wounds and in skin tumors.
The key to unravel the mechanism of MMP-10 action is the system…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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