CORDIS Project
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This project focuses on advancing technologies to study chromatin and transcription factor interactions in the genome. It aims to develop high-throughput systems for understanding epigenetic regulation and its implications for cancer detection and treatment.
Genes and genomic elements are packaged by chromatin structures that regulate their activity.
The fundamental unit of chromatin is the nucleosome, composed of an octamer of histones.
The large numbers of histone modifications, chromatin remodelers and transcription factors (TFs) that interact with our genome has fuelled speculation that multiple elements act combinatorially to direct specific outcomes.
However, the field lacks technologies for detection and analysis of such combinations, thus im…
WEIZMANN INSTITUTE OF SCIENCE
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