CORDIS Project
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This project investigates the role of G-quadruplexes in the biology of Trypanosoma parasites, aiming to develop peptide-based molecules that selectively target these structures. By understanding G4s' functions and their impact on gene expression, the project seeks to identify new therapeutic strategies against African…
African trypanosomiasis (AT), caused by the protozoan parasite Trypanosoma spp., is a debilitating disease that threatens millions of people in Sub-Saharan Africa.
The human disease evolves in two stages, the second of which causes a fatal neurological infection if left untreated.
The recent discovery of the orally-bioavailable drug fexinidazole, and its current use as a first-line treatment, has significantly improved disease outcomes associated with AT.
However, the risk of resistance to fexin…
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