CORDIS Project
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This research focuses on chromatin modifying enzymes that regulate gene expression and cell proliferation. It aims to develop small molecule inhibitors for these enzymes to explore their roles in diabetes and cancer treatment.
Chromatin modifying enzymes play important roles in the regulation of gene expression, the establishment and maintenance of distinct cell types during development and the control of cellular proliferation.
All of these features make them interesting targets for small molecule inhibitors that can function as probes for basic biological questions but also as lead compounds for drug development.
Indeed the first compounds inhibiting histone deacetylases and DNA methyltransferases have been approved…
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