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SMART-AML focuses on understanding the role of bone marrow adipose tissue in Acute Myeloid Leukemia. The project aims to manipulate this microenvironment to enhance chemotherapy effectiveness and reduce cancer relapse through advanced tissue engineering techniques.
Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy characterized by the uncontrolled proliferation of myeloid cells, which hijack the bone marrow (BM) and compromise its physiological functions. AML prognosis remains poor, with <10% of patients above 60 years old surviving after 5-years.
Recent discoveries have revealed the key role of BM microenvironment in harboring and protecting leukemic stem cells from chemotherapy, contributing to AML relapse.
Therefore, targeting the hij…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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