CORDIS Project
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This project investigates the role of sphingomyelinase enzymes in the signaling pathways of hypoxia and inflammation in pulmonary blood vessels. It aims to identify new therapeutic targets for conditions like chronic obstructive pulmonary disease and acute respiratory distress syndrome, focusing on their molecular mech…
Hypoxic pulmonary vasoconstriction (HPV) is a unique vasoconstrictor response that diverts blood flow away from poorly ventilated lung regions allowing ventilation-perfusion matching.
Despite being a highly conserved adaptive physiological mechanism in lung breathing vertebrates that optimizes blood oxygen saturation, hypoxia sensing in the lung plays a critical pathophysiological role in a number of pulmonary disorders. COPD is associated with chronic hypoxia and can lead in some patients to se…
UNIVERSIDAD COMPLUTENSE DE MADRID
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