CORDIS Project
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This project investigates the role of the SMAT complex in the regulation of gene expression in eukaryotic cells. By employing advanced techniques in structural biology and cell biology, it aims to understand how SMAT influences the assembly of transcription factors involved in gene regulation.
Transcription factor IID (TFIID) is a key player in regulated transcription of eukaryotic genes by RNA polymerase II.
The scaffold of TFIID is composed of a number of TATA-box binding protein-associated factors (TAFs), which are also found in other multimeric transcription factors (e.g. SAGA).
An elaborate system of decision-making therefore must occur that directs the assembly of TAFs into either TFIID or SAGA or other TAF containing complexes.
Recently, a multimeric 400 kDa small TAF-containin…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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