CORDIS Project
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This project investigates the role of specialized metabolites produced by the human gut microbiome in diseases like inflammatory bowel disease and colorectal cancer. It employs advanced bioinformatics and synthetic biology techniques to identify and analyze biosynthetic gene clusters and their biological effects.
Composition changes of the human gut microbiome has been associated with a series of diseases.
However, little is known about the mechanism of this microbiome alteration.
Recent in silico studies revealed thousands of biosynthetic gene clusters (BGCs) that encode diverse types of specialized metabolites from human microbiomes.
Many of these molecules are potentially involved in shaping microbiome structure or directly affect host cell and contribute to disease development.
To date, only colibact…
TECHNISCHE UNIVERSITAET DRESDEN
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