CORDIS Project
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This project aims to uncover the molecular mechanisms by which the condensin complex compacts DNA into chromosomes during cell division. Utilizing advanced imaging techniques, the research will explore how condensin interacts with DNA to facilitate its organization and condensation.
For division of each of our cells, 2 meters of DNA should be replicated, compacted into a few-micrometer size chromosomes that are segregated and distributed via mitosis, so that each daughter cell gets exactly one copy.
How this large DNA genome is well organized into such a small volume is one of the hottest issues for the understanding of chromosomes.
Condensin, a ring-like structure formed by SMC dimers, kleisin, and two heat domains, embraces DNA and condenses the DNA using ATP hydrolysis.…
TECHNISCHE UNIVERSITEIT DELFT
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