CORDIS Project
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This project aims to create an in vitro model of the Twin Arginine Translocation pathway using artificial lipid bilayers. It will utilize single-molecule imaging to study the transport of folded proteins across membranes, enhancing our understanding of bacterial protein export mechanisms.
The export of proteins across the cytoplasmic membrane is an essential function for all cells.
In bacteria, two distinct transport mechanisms are used:
The well-studied Sec pathway transports unfolded proteins via extrusion through a membrane-bound channel.
In contrast, much less is known regarding the Twin Arginine Translocation (Tat) pathway responsible for the transport of folded proteins.
The complexity required for this function is beyond that of a simple conformational change, and requires…
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