CORDIS Project
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This project investigates the mechanisms of protein sorting and trafficking in neurons, focusing on dendritic endosomes as critical stations for directing cargo to the axon. By uncovering these pathways, the research aims to enhance understanding of neuronal connectivity and develop potential therapies for neurodegener…
The high morphological and functional polarization of neuronal processes relies on exquisite mechanisms to accurately sort and traffic proteins to their rightful location.
It is therefore of no surprise that accurate formation and function of neuronal circuits depends on these trafficking mechanisms, which are indeed often impaired in neurodegenerative disorders and normal aging.
During the past 30 years, researchers have been able to dissect the mechanisms required to target proteins to the den…
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