CORDIS Project
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This research focuses on understanding how the immune system distinguishes between dying cells and pathogens during inflammation. By developing advanced tracking tools, it aims to elucidate the mechanisms of immune responses and their implications for autoimmune and infectious diseases.
During inflammation and infection, we are simultaneously confronted with both self and non-self in form of dying cells and microbes, respectively.
Mechanisms that facilitate the non-immunogenic clearance of self-antigens derived from apoptotic and necrotic cells and that, in parallel, allow the initiation of an immune response against invading pathogens are incompletely understood.
Recent data from our laboratory show that the immune system actively sorts apoptotic cells (ACs) and bacteria into…
UNIVERSITATSKLINIKUM ERLANGEN
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