CORDIS Project
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This project focuses on improving the accuracy of X-ray structure determination for biological macromolecules. By analyzing the effects of disordered solvent and developing new phase estimation methods, the project aims to enhance model quality, particularly for challenging structures like membrane proteins.
In X-ray structure determination, the R-value reports how well a model agrees with the experimental data.
In small molecule crystallography, R-values of 3% are routinely reached.
However, for biological macromolecules, R-values are normally around 20%, even when data extend to atomic resolution.
This is clear evidence that our current models of macromolecular crystal structures are severely and generally lacking.
But what is the difference between our models and reality?
And how can we improve o…
MEDICAL RESEARCH COUNCIL
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