CORDIS Project
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This project aims to enhance cancer immunotherapy for high-grade serous ovarian cancer by understanding how tumor genetics influence immune escape mechanisms. It utilizes advanced technologies to analyze tumor samples and develop patient-derived organoids for testing targeted treatments.
Tumor progression is dependent on the ability of malignant cells to escape the recognition and attack by the host immune system.
The development of more efficient cancer immunotherapies has been hampered by the perplexity of immune escape mechanisms. I hypothesize that tumor genetic drivers dictate the immune escape mechanisms, and that these mechanisms can be exploited to develop more effective immunotherapeutic strategies for patients with high-grade serous ovarian cancer (HGSC), the most comm…
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