CORDIS Project
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SPACE4AMPS focuses on developing new antimicrobial peptides to combat multidrug-resistant bacteria. By utilizing advanced computational tools and synthetic biology, the project aims to discover peptides with improved efficacy and reduced resistance potential.
Multidrug resistant (MDR) bacteria represent a global public health threat against which new drugs are urgently needed.
Antimicrobial peptides (AMPs), mostly derived from naturally occurring linear or cyclic peptides, can contribute to solving the problem. AMPs are already in clinical use, do not easily lead to resistance, and can rely on a strong manufacturing sector and established protocols for clinical development.
However, most AMPs are degraded by proteases and have poor pharmacokinetics.S…
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