CORDIS Project
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The SPARK project aims to develop advanced models of Parkinson's disease using induced pluripotent stem cells from patients and healthy individuals. By creating human dopamine neuron tissues and employing gene editing, the project seeks to understand disease mechanisms and develop personalized cell therapies for Parkin…
Loss of dopaminergic (DA) neurons in midbrain underlies motor dysfunction in Parkinsons disease (PD). PD is one of the most challenging neurodegenerative diseases to study due to the limitations of existing model systems in recapitulating its complex etiology resulting from individual risk variants, distinct genetic and epigenetic backgrounds, and age-related environmental triggers.
The SPARK project (Human Stem cell-based technologies to model PARKinsons disease and drive patient-specific cell…
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Sweden, Lund
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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