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The SPARXS project develops a technology to analyze the binding kinetics of affinity probes, specifically aptamers, using single-molecule observations and high-throughput sequencing. This innovative approach aims to enhance the design of probes for various applications in therapeutics and biochemical assays.
The binding kinetics of an affinity probethe speed and duration with which it attaches to a target moleculemust be precisely tuned for numerous applications in therapeutics, super-resolution microscopy, and biochemical assays.
The current methods of development lack the capability to specify these binding kinetics during probe design, resulting in the potential for effective drugs and relevant biological properties to remain undiscovered.
Here, I introduce a game-changing solution:
Single-molecu…
TECHNISCHE UNIVERSITEIT DELFT
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