CORDIS Project
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This project investigates how intrinsic properties of medial entorhinal cortex neurons affect spatial memory in rats. By manipulating specific ion channel subunits, it aims to establish a causal relationship between cell kinetics and grid cell firing patterns.
Behavioral unit recordings of rats exploring an open field have shown that medial entorhinal cortex (mEC) neurons have spatially specific firing fields that repeat at regular intervals.
Called ‘grid cells’, the field size and spacing of firing activity changes along the dorsal-ventral axis of mEC.
In vitro recordings of the same cell population has shown dorsal-ventral changes in the intrinsic properties of the cells; subthreshold oscillation frequency and the time constant of the hyperpolarizat…
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
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