CORDIS Project
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This project investigates the role of the Rc3h1 and Rc3h2 proteins in regulating gene expression in T cells, focusing on their interaction with ICOS mRNA. By understanding these mechanisms, the research aims to shed light on autoimmune disease development and improve immune response management.
We are constantly protected by our adaptive immune system.
Its functioning requires precise control of gene expression in lymphocytes, since deregulation can cause autoimmune diseases (affecting ~5% of our population) as well as allergic reactions (~9-16%, with increasing incidence).
Post-transcriptional control of gene expression is crucial in many immune decisions, however the determinants of specificity in this type of regulation are less well defined.
The recently described Rc3h1 or Roquin p…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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Germany, MUNCHEN
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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