CORDIS Project
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This project investigates the genetic and evolutionary factors influencing bacterial resistance to antibiotics. By using microbial experimental evolution and DNA sequencing, it aims to quantify how mutations affect resistance across different antibiotics and identify mechanisms that mitigate growth defects caused by th…
Bacterial resistance to antibiotics is a major problem for global public health, but we have an incomplete understanding of the evolutionary and genetic factors that drive the spread of resistance.
This proposal is motivated by the concept that some of the key processes in resistance evolution depend on the specificity of the genetic mechanisms involved, which is at present unclear.
Specificity here refers to variation of the phenotypic effects of mutations across genotypes (epistasis) or enviro…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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