CORDIS Project
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This project investigates the folding mechanisms of spectrin domains, which are crucial for maintaining cell membrane elasticity. By using single-molecule spectroscopy, it aims to understand how structural similarities among these domains lead to varying folding rates, providing insights into protein dynamics.
Spectrin domains R15, R16 and R17 are found in tandem arrays in proteins of the cytoskeleton, and spectrin itself is believed to be responsible for maintaining the shape of erythrocites by imparting elasticity to the cell membrane.
These three domains share virtually identical structure, stability, contact order, helical propensity, and transition state structure.
However, in spite of the striking structural resemblance and the apparently common function, these proteins fold to their native conf…
University of Zurich
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