CORDIS Project
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This project investigates the potential of spermidine, a compound that induces cellular quality control, as a treatment for hypertension. By exploring its effects on blood pressure regulation and autophagy mechanisms, the research aims to provide insights that could lead to new therapeutic strategies for managing hyper…
Hypertension pharmacotherapy, albeit fairly effective, is far from ideal and adequate blood pressure control is only achieved in one third of patients.
As such, hypertension is still the global leading cause of cardiovascular disease and mortality.
In this regard, we have recently discovered that higher intake of the caloric restriction mimetic spermidine – a potent inducer of the cellular quality control mechanism, autophagy – correlates with lower blood pressure in humans.
Administering spermi…
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