CORDIS Project
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This research investigates how cells establish polarity in multicellular environments, focusing on the role of cell adhesions and mechanical forces. It aims to develop experimental methods to manipulate these adhesions and understand their impact on tissue organization.
The functional coherence in multicellular arrangements depends on each cell’s ability to adapt its internal organisation to the spatial configuration of their microenvironment.
The asymmetric distributions of cell compartments and peripheral domains define the cell polarity.
In multicellular animals, the establishment of cell polarity is mainly regulated by the cell’s adhesions to its neighbours and to the surrounding extracellular matrix (ECM).
How cells integrate all these cues in space and ti…
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
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