CORDIS Project
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This project investigates the role of the hSpindly protein in regulating the spindle assembly checkpoint during cell division. By understanding its phosphorylation and function, the research aims to identify new therapeutic targets for cancer treatment, particularly for tumors resistant to anti-mitotic drugs.
During mitosis a sophisticated surveillance system, known as the spindle assembly checkpoint (SAC), is crucial to make sure that the cell does not separate its sister chromatids until all the chromosomes are correctly attached to spindle microtubules and bi-oriented.Nowadays, one of the more important strategy used for the cancer treatment is the inhibition of the microtubule dynamic to activate the SAC by the addition of anti-mitotic drugs.
At the end, the activation of SAC for a long period pr…
UNIVERSIDAD DE SEVILLA
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