CORDIS Project
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This project focuses on understanding how gene networks regulate the self-renewal and pluripotency of stem cells. It aims to identify mechanisms that control alternative splicing and its role in stem cell fate decisions, which could enhance therapeutic applications.
Adult, embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) possess the fundamental properties to self-renew while remaining pluripotent.
These unique capacities are regulated by gene networks which expression is tightly controlled at the epigenetic, transcriptional and post-transcriptional levels to insure proper stem cell fate decisions in response to developmental or environmental cues.
Alterations of these networks in cancer stem cells (CSC) support their tumorigenic activity…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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