CORDIS Project
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This project focuses on the molecular mechanisms of pre-mRNA splicing, specifically the assembly of the early spliceosomal complex. It aims to uncover structural insights that could enhance understanding of splicing regulation and its implications for human health.
Pre-mRNA splicing is the major step of RNA edition in eukaryotes.
It consists on a catalytic process that removes non-coding sequences (introns) and ligates the coding ones (exons), creating the RNA sequence that codifies the final protein.
This process is highly regulated and gives rise to a great variability of proteins, expanding the versatility encoded in the human genome.
In the early stage of splicing, RNA 5’ and 3’ splice sites must be brought within proximity to correctly assemble the ac…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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