CORDIS Project
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The project aims to enhance understanding of pre-mRNA splicing by investigating the activation of the spliceosome, a complex that processes RNA. Using advanced imaging techniques, it will explore the molecular changes that occur during the activation phase of splicing.
Pre-mRNA splicing is a fundamental maturation step of eukaryotic mRNAs that consists of the removal of introns and the concomitant ligation of exons by two successive transesterification reactions.
This complex biological process is catalyzed by the spliceosome, a gigantic ribonucleoprotein particle that assembles de novo on each intron and uses a single RNA-based active site to perform both reactions.
The spliceosome is composed of five snRNPs (U1, U2, U4, U5, U6) that are recruited to pre-mRNA…
UNITED KINGDOM RESEARCH AND INNOVATION
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