CORDIS Project
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This project investigates the structure and dynamics of the spliceosome, a crucial complex for RNA processing, using advanced imaging techniques like cryo-electron tomography. The goal is to visualize these complexes in their natural cellular environment, enhancing our understanding of pre-mRNA splicing mechanisms in h…
The spliceosome is a dynamic, multicomponent macromolecular complex essential for the precise removal of introns from pre-mRNA.
While extensive genetical, biochemical, and structural studies have provided insights into the splicing cycle, the structural dynamics and distribution of spliceosomes within human cells remain only partially understood.
In this project, I aim to study the in situ structures of the spliceosome by cryo-electron tomography (cryo-ET) and sub-tomogram averaging, alongside o…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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