CORDIS Project
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This project investigates the spliceosome's role in pre-mRNA splicing, focusing on how it maintains accuracy while accommodating alternative splicing. Using advanced cryo-electron microscopy, the research aims to uncover the molecular mechanisms that ensure splicing fidelity and how these processes are affected by cell…
In eukaryotes, the spliceosome removes non-coding introns from precursor messenger RNAs during pre-mRNA splicing.
Crucially, many pre-mRNAs are spliced differently depending on cellular status or external stimuli.
This “alternative splicing” reshapes the genetic information from a given mRNA to encode several protein isoforms and greatly diversifies proteomes.Splicing must be extremely precise as errors produce aberrant mRNA encoding potentially toxic proteins.
Splicing fidelity relies on the ac…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, Illkirch Graffenstaden
Type: Research institute
Activity type: Research Organisations
SME: No
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