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SPOTTER focuses on studying multimolecular G-quadruplex structures in the human genome, which are important for understanding DNA function and disease mechanisms. The project aims to develop a selective probe for live-cell imaging and genome-wide mapping of these structures, particularly in relation to neurodegenerativ…
G-quadruplex structures (G4s) are gaining attention due to their widespread presence in the human genome, featuring over 700,000 identified sequences.
These stable G4s are often found in critical areas of our DNA, such as telomeres, gene promoters, and regions linked to repeat expansions in diseases.However, when investigating their biological function, multimolecular G-quadruplexes (mG4s) have been often overlooked and deemed unlikely to be physiologically relevant, with the bulk of recent adva…
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