CORDIS Project
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This project explores a novel method of attaching drugs to squalene to create nanoparticles for targeted drug delivery. The focus is on developing a less toxic synthesis process for a specific anticancer drug, aiming to improve treatment efficacy and reduce side effects.
In the course of the ERC Advanced Grant TERNANOMED, we have discovered that the linkage of squalene (a natural lipid) to many drugs, confers to the resulting bioconjugates the remarkable property to self-assemble as nanoparticles, due to the folded molecular conformation of squalene.
This approach is unique and has never been used before.
The so called ""squalenoylation"" technology may be considered as a generic platform to construct nanomedicines with high drug loading and targeted drug releas…
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