CORDIS Project
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This project explores the role of small RNA molecules, specifically piwi-interacting RNAs, in regulating DNA replication and maintaining genome stability in the fruit fly model. It aims to uncover how these small RNAs influence DNA copy number and epigenetic inheritance through heterochromatin formation.
Small RNA-mediated gene regulation and DNA replication are fundamental genome-regulatory pathways essential for cellular life, organismal development, and disease prevention.
While small RNA pathways are known to sequence-specifically regulate DNA copy number in some unicellular animals, such connections have yet to be found in multicellular animals.
With this project, I will investigate and mechanistically characterize such a potential connection in the Drosophila animal model system.
Piwi-inte…
AARHUS UNIVERSITET
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